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Items Exempt from, Infectious Substances Shipping Regulations

  • Substances which do not contain infectious substances or which are unlikely to cause diseases in humans or animals.

  • Substances containing micro-organisms, which are non-pathogenic to humans or animals.

  • Substances in a form that any present pathogens have been neutralized or inactivated in such a way that they are no longer a health risk to humans or animals.

  • Environmental samples (including food and water samples), which are not considered to pose a significant risk of infection to humans or animals.

  • Dried blood spots, collected by applying a drop of blood onto absorbent material, or fecal occult blood screening tests and blood or blood components which have been collected for the purposes of transfusion or for the preparation of blood products to be used for transfusion of transplantation and any tissues or organs intended for use in transplantation.

  • Non-infectious biological material from humans, animals, or plants. Examples include non-infectious cells, tissue cultures, blood or plasma from individual not suspected of having an infectious disease, DNA, RNA, or other genetic elements.

  • Patient specimens for which there is minimal likelihood that pathogens are present if the specimen is packaged in a manner that will prevent any leakage and that is marked, “Exempt human specimen” or “Exempt animal Specimen.” Consult IATA/DOT regulations concerning packaging specifications. Examples of specimens which meet this criteria include blood or urine tests to monitor cholesterol levels, blood glucose levels, hormone levels, prostate specific antigens; test required to monitor organ function (ex. Heart, liver, or kidney) for humans or animals with non-infectious diseases or therapeutic drug monitoring; blood tests to determine the presence of drugs or alcohol for insurance or employment purposes; pregnancy tests; biopsies to detect cancer; and antibody detection in humans or animal.

  • A biological product, experimental or investigational , subject to federal approval, permit, review or licensing requirements such as those required by the Food and Drug Administration or the US Department of Agriculture.

Appendix A – Indicative Examples of Category A Infectious Substances -*Note this list is not exhaustive.

UN # and Proper

Shipping Name


UN 2814

Infectious Substances affecting humans

- Bacillus anthracis cultures

- Brucella abortus cultures

- Brucella melitenis cultures

- Brucella suis cultures

- Burkholderia mallei – Psedomonas mallei

Glanders cultures

- Burholderia pseudomallei – Pseudomonas

pseudomallei cultures

- Chlamydia psittaci – avian strains cultures

- Clostridium botulinum cultures

- Coccidioides immittis cultures

- Coxiella burnetti cultures

- Crimean-Congo hemorrhagic fever virus

- Dengue virus cultures

- Eastern equine encephalitis virus cultures

- Escherichia coli, verotoxigenic cultures

- Ebola virus

- Flexal virus

- Francisella tularnesis cultures

- Guanarito virus

- Hantaan virus

- Hantaviruses causing hemorrhagic fever with

renal syndrome

- Hendra virus

- Hepatitis B virus cultures

- Herpes B virus cultures

- Human immunodeficiency virus cultures

- Highly pathogenic avian influenza virus cultures

- Japanese Encephalitis virus cultures

- Junin virus

- Kyasanur Forest disease virus

- Lass virus

- Machupo virus

- Marburg virus

- Monkeypox virus

- Mycobacterium tuberculosis cultures

- Nipah virus

- Omsk hemorrhagic fever virus

- Poliovirus cultures

- Rabies virus (cultures only)

- Rickettsia prowazekii cultures

- Rickettsia rickettsia cultures

- Rift Valley fever virus (cultures only)

- Russian spring-summer encephalitis virus cultures

- Sabia virus

- Shigella dysenteriae type 1 cultures

- Tick-borne encephalitis virus cultures

- Variola virus

- Venezuelan equine encephalitis virus (cultures


- West Nile virus cultures

- Yellow fever virus cultures

- Yersinia pestis cultures

UN 2900

Infectious substance affecting animals

- African swine fever virus (cultures only)

- Avian paramyxoviurs Type 1- Velogenic Newcastle disease virus (cultures only)

- Classical swine fever virus (cultures only)

- Foot and mouth disease virus (cultures only)

- Lumpy skin disease virus (cultures only)

- Mycoplasma mycoides – Contagious bovine pleuropneumonia (cultures only)

- Peste des petits ruminants virus (cultures only)

- Rinderpest virus (cultures only)

- Sheep pox virus (cultures only)

- Goatpos virus (cultures only)

- Swine vesicular disease virus (cultures only) Vesicular stomatitis virus (cultures only)

Dangerous Goods in Excepted Quantities

  1. Training:

Shipments of excepted dangerous goods are subject to all training requirements set forth by DOT/IATA regulations. Anyone offering hazardous materials for transport must first receive training. Those wishing to ship hazardous materials according to the exceptions in 49 CFR §173.4 must receive personal training from EH&S. Call EH&S at 828-1392 to schedule a shipping training.

  1. Materials with exceptions:

The materials covered by the small quantity exceptions include:

    • Non-flammable/non-toxic gases with no subsidiary risk;

    • Flammable liquids;

    • Flammable solids in packing groups II and III only, but excludes self reactive substances;

    • Spontaneously combustible materials in packing groups II and III only;

    • Dangerous when wet materials in packing groups II and III only;

    • Oxidizers in packing groups II and III only;

    • Organic peroxides in packing group II only;

    • Toxic substances; and

    • Corrosives in packing groups II and III only.

  1. Materials with no exceptions – A Dangerous Goods Declaration is always required

Materials for which there are no exceptions to DOT/IATA regulations include:

  • Explosives;

  • Flammable and Toxic Gases;

  • Flammable solids with subsidiary risk;

  • Oxidizers found in packing group I;

  • Organic peroxides;

  • Infectious substances;

  • Corrosives found in packing group I, gallium, and mercury;

  • Magnetized materials and

  • Carbon dioxide solid (Dry Ice).

  1. Requirements for the shipment of excepted goods

Materials covered by the small quantity exceptions are exempt from all other requirements of IATA/ DOT 49 CFR when they are shipped according the requirements outlined below. For full text of these requirements, see the IATA Dangerous Goods Regulations Section 2 and DOT regulation 49 CFR 173.4. Briefly, these requirements are:

      1. Inner receptacle contains not more than 30 ml or 30 g of hazardous material.

      2. Inner receptacle is at least 0.2 mm thick and maintains adequate ullage at 55 °C.

      3. Closure of inner receptacle is positively secured.

      4. Absorbent and/or cushioning requirements.

      5. Inner receptacle is secured in outer packaging.

      6. Prototype packaging must pass a drop test and compressive load test.

      7. Package must not contain forbidden materials; see Part C above.

      8. Package does not exceed 29 kg.

      9. Package is not opened or altered during transportation.

      10. The package is labeled with the, “Dangerous goods in excepted quantities,” declaration.

  1. Labeling Requirements:

Each package containing a dangerous good in excepted quantities must be labeled with a label having minimum dimensions of 100 x 100 x 100 mm (4 x 4 in) which conforms in shape, color, format and text as specified by IATA and DOT.

      1. A label must be clearly visible and affixed or printed on the package on a contrasting background. Overpacks will also need to be labeled

      2. The shippers must check the boxes on the label that corresponds to the primary, and where applicable, subsidiary risk for each dangerous good contained in the package.

      3. The shipper must also fill in the following:

  • Name

  • Shippers address

  • Position Title

  • Date

      1. The shipper must sign the declaration as indicated

      2. The border of the label must have red diagonal hatching.

A representative sample of the Excepted Quantities Label is below (not drawn to regulator scale):

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